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"Response of Stressors Pioneer" Hans Selye, MD Hand Signed Biography Page For Sale



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"Response of Stressors Pioneer" Hans Selye, MD Hand Signed Biography Page:
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Up for sale "Response of Stressors" Hans Selye Hand Signed Bio Page. 



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János Hugo János; January 26, 1907 – October 16, 1982), was a pioneering Hungarian-Canadian endocrinologist. He conducted important scientific work on the hypothetical non-specific response of an organism to stressors. Although he did not recognize all of the many aspects of glucocorticoids, Selye was aware of their role in the stress response. Charlotte Gerson considers him the first to demonstrate the existence of biological stress. Selye was born in Vienna, Austria-Hungary on January 26, 1907 and grew up in Komárom, Hungary. Selye's father was a doctor of Hungarian ethnicity and his mother was Austrian. He became a Doctor of Medicine and Chemistry in Prague in 1929 and went on to do pioneering work in stress and endocrinology at Johns Hopkins University, McGill University, and the Université de Montréal. He was nominated for the Nobel prize in Physiology or Medicine for the first time in 1949. Although he received a total of 17 nominations in his career, he never won the prize. Selye died on October 16, 1982 in Montreal, Quebec, Canada. He often returned to visit Hungary, giving lectures as well as interviews in Hungarian television programs. He conducted a lecture in 1973 at the Hungarian Scientific Academy in Hungarian and observers noted that he had no accent, despite spending many years abroad. His bookThe Stress of Life appeared in Hungarian as Az Életünk és a stressz in 1964 and became a bestseller. Selye János University, the was named after him. Selye's mother was killed by gunfire during Hungary's anti-Communist revolt of 1956. Selye's interest in stress began when he was in medical school; he had observed that patients with various chronic illnesses like tuberculosis and cancer appeared to display a common set of symptoms that he attributed to what is now commonly called stress. After completing his medical degree and a doctorate degree in organic chemistry at the German University of Prague, he received a Rockefeller Foundation fellowship to study at Johns Hopkins in Baltimore and later moved to the Department of Biochemistry at McGill University in Montreal where he studied under the sponsorship of James Bertram Collip. While working with laboratory animals, Selye observed a phenomenon that he thought resembled what he had previously seen in chronic patients. Rats exposed to cold, drugs, or surgical injury exhibited a common pattern of responses; this "general adaptation syndrome" or "Selyes syndrome" was triphasic, involving an initial alarm phase followed by a stage of resistance or adaptation and, finally, a stage of exhaustion and death. Working with doctoral student Thomas McKeown (1912–88), Selye published a report that used the word “stress” to describe these responses to adverse events. His last inspiration for general adaptation syndrome (GAS, a theory of stress) came from an endocrinological experiment in which he injected mice with extracts of various organs. He at first believed he had discovered a new hormone, but was proved wrong when every irritating substance he injected produced the same symptoms (swelling of the adrenal cortex, atrophy of the thymus, gastric and duodenal ulcers). This, paired with his observation that people with different diseases exhibit similar symptoms, led to his description of the effects of "noxious agents" as he at first called it. He later coined the term "stress", which has been accepted into the lexicon of most other languages. Selye has acknowledged the influence of Claude Bernard (who developed the idea of milieu intérieur) and Walter Cannon's "homeostasis". Selye conceptualized the physiology of stress as having two components: a set of responses which he called the "general adaptation syndrome", and the development of a pathological state from ongoing, unrelieved stress. Selye discovered and documented that stress differs from other physical responses in that stress is stressful whether one receives good or bad news, whether the impulse is positive or negative. He called negative stress "distress" and positive stress "eustress". The system whereby the body copes with stress, the hypothalamic-pituitary-adrenal axis (HPA axis) system, was also first described by Selye. He also pointed to an "alarm state", a "resistance state", and an "exhaustion state", largely referring to glandular states. Later he developed the idea of two "reservoirs" of stress resistance, or alternatively stress energy. Selye wrote The Stress of Life (1956), From Dream to Discovery: On Being a Scientist (1964) and Stress without Distress (1974). He worked as a professor and director of the Institute of Experimental Medicine and Surgery at the Université de Montréal. In 1975 he created the International Institute of Stress, and in 1979, Dr. Selye and Arthur Antille started the Hans Selye Foundation. Later Selye and eight Nobel laureates founded the Canadian Institute of Stress. In 1968 he was made a Companion of the Order of Canada. In 1976, he was awarded the Loyola Medal by Concordia University. 



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