"Response of Stressors Pioneer" Hans Selye Hand Signed Album Page for Sale

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"Response of Stressors Pioneer" Hans Selye Hand Signed Album Page For Sale

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"Response of Stressors Pioneer" Hans Selye Hand Signed Album Page:
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Up for sale "Response of Stressors" Hans Selye Hand Signed Album Page.

ES-4896

János

Hugo János; January 26, 1907 – October 16, 1982),

was a pioneering Hungarian-Canadian endocrinologist. He conducted important scientific work on the

hypothetical non-specific response of an organism to stressors. Although he did not recognize all of the many

aspects of glucocorticoids, Selye was

aware of their role in the stress response. Charlotte Gerson considers him the first to demonstrate the

existence of biological stress. Selye

was born in Vienna, Austria-Hungary on January 26, 1907 and grew up in Komárom, Hungary. Selye's father was a doctor of Hungarian ethnicity and his mother was Austrian. He became a Doctor

of Medicine and Chemistry in Prague in 1929 and went on to do

pioneering work in stress and endocrinology at Johns Hopkins University, McGill University, and the Université de Montréal. He

was nominated for the Nobel prize in

Physiology or Medicine for the first time in 1949. Although he received a total

of 17 nominations in his career, he never won the prize. Selye

died on October 16, 1982 in Montreal, Quebec, Canada. He often returned to visit Hungary,

giving lectures as well as interviews in Hungarian television programs. He

conducted a lecture in 1973 at the Hungarian Scientific Academy in Hungarian

and observers noted that he had no accent, despite spending many years abroad.

His bookThe Stress of Life appeared in Hungarian as Az

Életünk és a stressz in 1964 and became a bestseller. Selye János University,

the was named after him. Selye's mother was killed by

gunfire during Hungary's anti-Communist revolt of 1956. Selye's interest in

stress began when he was in medical school; he had observed that patients with

various chronic illnesses like tuberculosis and cancer appeared to display a

common set of symptoms that he attributed to what is now commonly called stress.

After completing his medical degree and a doctorate degree in organic chemistry

at the German University of Prague, he received a Rockefeller Foundation

fellowship to study at Johns Hopkins in Baltimore and later moved to the

Department of Biochemistry at McGill University in Montreal where he studied

under the sponsorship of James Bertram Collip. While working with laboratory animals, Selye

observed a phenomenon that he thought resembled what he had previously seen in

chronic patients. Rats exposed to cold, drugs, or surgical injury exhibited a

common pattern of responses; this "general adaptation syndrome" or

"Selyes syndrome" was triphasic, involving an initial alarm phase

followed by a stage of resistance or adaptation and, finally, a stage of

exhaustion and death. Working with doctoral student Thomas McKeown

(1912–88), Selye published a report that used the word “stress” to describe

these responses to adverse events. His last

inspiration for general adaptation

syndrome (GAS, a theory of stress) came from an endocrinological experiment in which he

injected mice with extracts of various organs. He at first believed he had

discovered a new hormone, but was proved wrong when every irritating substance

he injected produced the same symptoms (swelling of the adrenal cortex, atrophy of the thymus, gastric and duodenal ulcers). This, paired with his observation that people

with different diseases exhibit similar symptoms, led to his description of the

effects of "noxious agents" as he at first called it. He later coined

the term "stress", which has

been accepted into the lexicon of most other languages. Selye has

acknowledged the influence of Claude Bernard (who developed the idea of milieu intérieur)

and Walter Cannon's "homeostasis". Selye conceptualized the physiology of

stress as having two components: a set of responses which he called the "general adaptation

syndrome", and the development of a pathological state from

ongoing, unrelieved stress. Selye discovered and documented that stress differs

from other physical responses in that stress is stressful whether one receives

good or bad news, whether the impulse is positive or negative. He called

negative stress "distress" and