RARE \"Warfarin Creator\" Karl Link Hand Written Note On 3X5.5 Card Dated 1960 For Sale

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RARE \"Warfarin Creator\" Karl Link Hand Written Note On 3X5.5 Card Dated 1960:
$489.99

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for sale a RARE! "Warfarin" Karl Link Hand Written TLS On 3X5.5 Card Dated 1960 regarding his greatest accomplishment. 

ES-2550C

Karl Paul Gerhard Link (31 January 1901 – 21 November 1978) was an American

biochemist best known for his discovery of the anticoagulant warfarin. He was

born in LaPorte, Indiana to a Lutheran minister of German descent as one of ten

children. He was schooled locally, and attended the University of Wisconsin–Madison,

where he studied agricultural chemistry at the College of Agriculture from 1918

to 1925, obtaining an MS in 1923 and a PhD in 1925. He was then chosen by the

national Education Board for a postdoctoral scholarship, and relocated to

Europe. He briefly worked with carbohydrate chemist Sir James Irvine at the

University of St Andrews in Scotland and from 1926 in Graz, Austria with Fritz

Pregl, inventor of microchemistry and Nobel Laureate. Finally he spent several

months with organic chemist and future Nobel laureate Paul Karrer in the

latter's lab in Zurich; during this period Link suffered from tuberculosis,

requiring recuperation in Davos. After his return from Europe, he acquired his

taste for dressing eccentrically, as he was often seen in large bow ties,

flannel shirts, and sometimes a cape. He was offered an assistant professorship

at the University of Wisconsin–Madison in 1927, and was promoted to associate

professor in 1928. He worked initially on plant carbohydrates and resistance to

disease. He married Elizabeth Feldman on September 20, 1930; they were to have

three sons.  In the subsequent years,

most of his research focused on plant carbohydrates. However, the most fruitful

period began when Ed Carson, a Wisconsin farmer, attracted Link's attention to

"sweet clover disease", described in 1924 by veterinarian Frank

Schofield. In this condition, cows bled to death after consuming hay made from

spoilt sweet clover. Carson's stock had been affected, and he brought a dead

cow, blood that would not clot, and 100 pounds of sweet clover hay. Under the

direction of Link, PhD students Harold Campbell, Ralph Overman, Charles

Huebner, and Mark Stahmann crystallised the putative poison—a coumarin-related

compound—and synthetised and tested it; it turned out to be hydroxycoumarin)). Dicoumarol was subjected to clinical

trials in Wisconsin General Hospital and the Mayo Clinic. It was for several

years the most popularly prescribed oral anticoagulant. Warfarin, one of the

several compounds synthesised as part of the coumarin research, was patented in

1945. The patent was assigned to the Wisconsin Alumni Research Foundation

(WARF), for which reason it was given the name Warfarin. Link and researchers

Stahmann and Ikawa jointly owning the patent. Initially marketed as rat poison,

warfarin would later, in the 1950s, become the second most important

anticoagulant for clinical use (after heparin).Link was elected to the National

Academy of Sciences in 1946. He received several awards for his work, including

the 1955 Albert Lasker Award for Basic Medical Research and the 1960 Albert

Lasker Award for Clinical Medical Research. He remained closely involved in the

biochemistry of warfarin and related compounds. His work in later years was

hampered by poor health (tuberculosis) as he was then relocated to Lake View

sanatorium, and upon his return was never able to fully regain his momentum in

research. Nevertheless, he remained a full professor until 1971, when he

retired. He was a lifelong pioneer of liberal causes, and his wife was active

in the pacifist movement. Link died from heart failure on November 21, 1978. 

RARE "Warfarin Creator" Karl Link Hand Written Note On 3X5.5 Card Dated 1960

$489.99

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