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RARE “Experimental Medicine Pioneer\" Edwin E. Osgood Hand Signed TLS Dated 1961 For Sale


RARE “Experimental Medicine Pioneer\
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RARE “Experimental Medicine Pioneer\" Edwin E. Osgood Hand Signed TLS Dated 1961:
$349.99

Up for sale "Experimental Medicine" Edwin E. Osgood Hand Signed TLS Dated 1961. 


ES-4220

A caring clinician,

careful researcher, and inspirational teacher, Edwin E. Osgood made lasting

contributions to hematology and experimental medicine. A native of Fall River,

Massachusetts, Osgood first came to the University of Oregon Medical School

(UOMS) in 1918, joining both the student body and the staff as an assistant in

biochemistry. He received his masters and M.D. degrees in 1924 and was

appointed to the faculty as director of laboratories in 1928. In 1936, he was

made head of the newly formed Division of Experimental Medicine, becoming the

only physician on the full-time faculty. Osgood’s tenure in Oregon was long and

fruitful. He performed one of the first bone marrow aspiration analyses in the

United States, and was the first to establish normal values for specimens,

improving our understanding of abnormal blood cell production in disease. In

1936, with student Inez E. Brownlee, he developed a method for culturing human

bone marrow outside the body. This advance was hailed by the American Medical

Association as “a development with more promise than the artificial heart.” In

1939, Osgood applied what he had learned about bone marrow to therapy and

attempted the first bone marrow transplant on a patient with aplastic anemia. Osgood

studied the life span of white blood cells and paved the way to the development

of a method for culturing these cells in the diseased state known as leukemia.

In 1941, he began using a type of controlled radiation therapy for leukemia

patients. In 1957, he presented a unifying hypothesis of the cause of cancer,

proposing that the absence of regulating chemicals that normally control cell

growth might be responsible. His hypothesis brought together multiple

hypotheses then in vogue, almost all of which focused exclusively on types of

cell damage that could cause cell proliferation. Twenty years later, after the

development of newer bone marrow culturing techniques, Osgood’s malignancy

hypothesis was confirmed. In 1962, Osgood’s team was the first to successfully

unwind a human chromosome by placing blood cells in a solution, making it

possible to study the structure of this basic unit. At some point in his career,

Osgood taught nearly every class at UOMS, and he oversaw clerkships six days a

week from 1924 to 1946. He once remarked that medical education is “like trying

to build a skyscraper on the foundation for a hut”— without the proper

grounding in the basic sciences, students won’t understand why certain concepts

are important. Osgood officially retired from the medical school in January

1969 and died the following October. At that time, Dean Charles Holman

remarked: “I know of no one who has been any more dedicated to medical

education and medical science…and his work here at the Medical School…has had a

significant influence on our teaching, research, and patient care programs.” 



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