\"Riboswitch Mechanism\" Charles Yanofsky Signed 4X5 B&W Photo For Sale

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\"Riboswitch Mechanism\" Charles Yanofsky Signed 4X5 B&W Photo:
$299.99

Up for sale "Riboswitch Mechanism" Charles Yanofsky Hand Signed 4X5 B&W Photo. 

1925– March 16, 2018) was an American geneticist on the faculty of Stanford University who

contributed to the establishment of the one gene-one enzyme hypothesis and

discovered attenuation, a riboswitch mechanism in which messenger RNA changes

shape in response to a small molecule and thus alters its binding ability for

the regulatory region of a gene or operon. Charles Yanofsky was born on April

17, 1925 in New York. He was one

of the earliest graduates of the Bronx High School of Science, then studied at the City College of New York and

completed his degree in biochemistry in spite of having had his education

interrupted by military service in World War II including participation in the

Battle of the Bulge. In 1948, having returned and completed college, he

took up graduate work towards his master's degree and PhD, both granted

by Yale University. He

pursued postdoctoral work at Yale for a time, completing work started during

his PhD training. Yanofsky joined the Case Western Reserve Medical School

faculty in 1954. He moved to the faculty at Stanford University

as an Associate Professor in 1958. In 1964, Yanofsky and colleagues established

that gene sequences and protein sequences are colinear in bacteria. Yanofsky showed that changes in DNA sequence can produce changes in protein sequence at

corresponding positions. His work is considered the best evidence in

favor of the one gene-one enzyme hypothesis.His laboratory also revealed how

controlled alterations in RNA shapes allow RNA to serve as a

regulatory molecule in both bacterial and animal cells. His graduate student Iwona Stroynowski and Mitzi Kuroda discovered the process of attenuation of

expression based on regulated binding ability of the five-prime untranslated

region of the messenger RNA for the bacterial tryptophan operon. They

had thus discovered the first regulatory riboswitch, although that terminology was not used until

later. Yanofsky and his other collaborators then extended this work showing how

mRNAs responded allosterically to a small molecule signal by changing shape and

therefore changing ability to bind to the regulatory region of each operon.

They showed that this mechanism applied to other amino acid biosynthesis and

degradation operons of bacteria and to animal cell genes. In

1980, Yanofsky and other Stanford scientists founded DNAX, a Palo Alto-based

research institute subsequently acquired by Schering-Plough. Yanofsky

died in Palo Alto, California. At the time of death, he was the Morris Herzstein

Professor of Biology and Molecular Biology (Emeritus) in the Department of

Biology at Stanford University. 

"Riboswitch Mechanism" Charles Yanofsky Signed 4X5 B&W Photo

$299.99