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"Nobel Prize in Medicine" Arthur Kornberg Signed 2X4 Card Display COA For Sale



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"Nobel Prize in Medicine" Arthur Kornberg Signed 2X4 Card Display COA:
$139.99

Up for sale the"Nobel Prize in Medicine" Arthur Kornberg Signed 2X4 Card Display.This item is certified authentic by JGAutographs and comes with their Certificate of Authenticity.
ES-8402
Arthur Kornberg(March 3, 1918 – October 26, 2007) was anAmericanbiochemistwho won theNobel Prize in Physiology or Medicine1959 for his discovery of "the mechanisms in thebiological synthesisofdeoxyribonucleic acid(DNA)" together with Dr.Severo OchoaofNew York University. He was also awarded thePaul-Lewis Award in Enzyme Chemistryfrom theAmerican Chemical Societyin 1951, L.H.D. degree fromYeshiva Universityin 1962, as well asNational Medal of Sciencein 1979. In 1991, Kornberg received the Golden Plate Award of theAmerican Academy of Achievementand theGairdner Foundation Awardin 1995. His primary research interests were inbiochemistry, acidsynthesis (DNA replication) and studying the nucleic acids which control heredity in animals, plants, bacteria and viruses. Born inNew York City, Kornberg was the son ofJewishparents Joseph and Lena (née Katz) Kornberg, who emigrated to New York fromAustrian Galicia(now part ofPoland) in 1900 before they were married. His paternal grandfather had changed the family name from Queller (also spelled Kweller) to avoid the draft by taking on the identity of someone who had already completed military service. Joseph married Lena in 1904. Joseph worked as a sewing machine operator in the sweat shops of theLower East side of New Yorkfor almost 30 years, and when his health failed, opened a small hardware store inBrooklyn, where Arthur assisted customers at the age of nine. Joseph spoke at least six languages although he had no formal education. Arthur Kornberg was educated first atAbraham Lincoln High Schooland then atCity CollegeinNew York City. He received at B.Sc. in 1937, followed by anM.D.at theUniversity of Rochesterin 1941. Kornberg had a mildly elevated level ofbilirubinin his blood—jaundicedue to ahereditarygenetic condition known asGilbert's syndrome—and, while at medical school, he took a survey of fellow students to discover how common the condition was. The results were published in Kornberg's first research paper in 1942.Kornberg's internship was atStrong Memorial HospitalinRochester, New York, between 1941–1942. After completing his medical training, he joined the armed services as a lieutenant in theUnited States Coast Guard, serving as a ship's doctor in 1942.Rolla Dyer, the Director ofNational Institutes of Health, had noticed his paper and invited him to join the research team at the Nutrition Laboratory of the NIH. From 1942 to 1945, Kornberg's work was the feeding of specialized diets to rats to discover new vitamins. The feeding of rats was boring work, and Kornberg became fascinated byenzymes. He transferred toDr Severo Ochoa'slaboratory atNew York Universityin 1946, and took summer courses atColumbia Universityto fill out the gaps in his knowledge of organic and physical chemistry while learning the techniques of enzyme purification at work. He became Chief of the Enzyme and Metabolism Section at NIH from 1947–1953, working on understanding ofATPproduction fromNADandNADP. This led to his work on how DNA is built up from simplermolecules. While working at NIH, he also researched atWashington University in St. Louis(in the lab ofCarl Ferdinand CoriandGerty Coriin 1947), and theUniversity of California, Berkeley(in the lab ofHorace Barkerin 1951).In 1953 he became Professor and Head of the Department of Microbiology, Washington University in St. Louis, until 1959. Here he continued experimenting with the enzymes which created DNA. In 1956 he isolated the first DNA polymerizing enzyme, now known asDNA polymerase I. This won him the Nobel prize in 1959.In 1960 he received aLL.D.again from City College, followed by aD.Sc.at theUniversity of Rochesterin 1962. He became Professor and Executive Head of the Department of Biochemistry,Stanford University, in 1959. In an interview in 1997, Arthur Kornberg (referring toJosh Lederberg) said: "Lederberg really wanted to join my department. I knew him; he's a genius, but he'd be unable to focus and to operate within a small family group like ours, and so, I was instrumental in establishing a department of genetics [at Stanford] of which he would be chairman."Kornberg's mother died of gas gangrene from asporeinfection after a routinegall bladderoperation in 1939. This started his lifelong fascination with spores, and he devoted some of his research efforts to understanding them while at Washington University. From 1962 to 1970, in the midst of his work on DNA synthesis, Kornberg devoted half his research effort to determining how DNA is stored in the spore, what replication mechanisms are included, and how the spore generates a newcell. This was an unfashionable but complex area of science, and although some progress was made, eventually Kornberg abandoned this research. The Arthur Kornberg Medical Research Building at theUniversity of Rochester Medical Centerwas named in his honor in 1999. Until his death, Kornberg maintained an active research laboratory at Stanford and regularly published peer reviewed scientific journal articles. For several years the focus of his research was the metabolism ofinorganicpolyphosphate. The "Kornberg school" of biochemistry refers to Arthur Kornberg's many graduate students and post-doctoral fellows, i.e., his intellectual children, and the trainees of his trainees, i.e., his intellectual grandchildren. Kornberg's intellectual children includeI. Robert Lehman,[2]Charles C. Richardson,Randy Schekman,William T. Wickner,James Rothman,Arturo FalaschiandKen-ichi Arai.


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